Your Local Pharmacy in Hamilton, ON

McKnight's Pharmacy has two locations on Main Street East in Hamilton, at 685 Main St E and at our Pharmacy & Compounding Centre at 460 Main St E. Our pharmacists get to know you by name and help with prescriptions, minor ailments, vaccines, MedsChecks, blister packs and free Hamilton delivery. We also ship across Canada.

Healthcare professional in scrubs with a stethoscope, arms crossed

McKnight's Pharmacy has two locations on Main Street East in Hamilton. Custom compounded medications are prepared at our 460 Main St E Pharmacy & Compounding Centre. Visit us at 685 or 460 Main St E, or enjoy free prescription delivery across Hamilton.

Let Us Take Care of You

Request A Refill: 685 Main Street East Hamilton location (main and proctor)Request a Refill: 460 Main Street East Hamilton location (main and ontario)

Online weight loss clinic, Minor Ailment Consult & Vaccine Appointment

Virtual Weight Loss Clinic
Struggling to lose weight? See our licensed physicians through our virtual clinic
Click here to book
Minor Ailment Consult
Pharmacists can now prescribe for certain conditions! Book an appointment today
Click here to book at our 685 Main Street E location
Vaccines
As of October 2026, we're accepting walk-ins for:
Flu Shots
COVID-19 boosters coming soon

Close-up of colourful medication capsules

How We Serve You

✔️ Conveniently refill your prescriptions via chat on Google Maps, online, email, or call us!

✔️ All drugs plan accepted.

✔️ Free prescription pickup and same day delivery.

✔️ Free blister & compliance packaging.

✔️ Free delivery to all areas of Hamilton.

✔️ Free medication synchronization.

✔️ Free Pill cutting/splitting service.

✔️ Friendly and helpful staff.

✔️ Private consultation with our pharmacist.

✔️ At home or in-store medication reviews.

✔️ Non-Sterile Compounding specialists.

✔️ Diabetes & Pain Management.

About McKnight's Pharmacy

HOME MEDICAL EQUIPMENT & SUPPLIES

We provide a variety of home health care products, that can be shipped right to your door!
Check out our partners:
Living at home support | Live Easy Inc.
DIABETIC SUPPLIES

Our pharmacy team provides training for all diabetic meters and devices. We'll help you monitor your sugar levels by providing specific meal plans, exercise tips and more!
VACCINATIONS

Protect yourself and those you care about by getting the annual influenza vaccine available at our pharmacy starting in November. All walk-ins are welcome!
COMPOUNDING & PRESCRIPTION DRUGS

Taking medicine can be a scary thing. That's why we do our best to educate our clients on every medication and its potential adverse effects, while preventing interactions with other drugs! Unable to swallow that pill? We'll make it into something you can take to ensure you get the right medication at the right dose!